Computer simulations are a powerful method to study physical and engineering systems such as fluids, collections of molecules, or social agents. Traditionally, differential equations such as the Navier-Stokes equations form the basics of performing simulations as they dictate the time evolution. A recent, promising development is to use machine learning for model-free prediction of a systems’ behavior and to identify the appearance of spatio-temporal patterns. Deep learning with neural networks is a particularly interesting and powerful machine learning method that can be employed for this task.